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A hydrophobic site on the GLP-1 receptor extracellular domain orients the peptide ligand for signal transduction

Last weeks JAMA had two articles on GLP-1 drugs that point to their promise for treatment of diseases beyond the conditions for which they are already approved by the FDA: obesity, diabetes, cardiovascular risk, sleep apnea and metabolic liver disease

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Zheng, Q., Zhang, S., Guo, W